Disability research for gigantism/acromegaly !

Instructions

So, gigantism is VERY rare and can be summed up as some kind of underlying issue found in the pituitary gland located at the base of the skull. Let it either be genetics, enlargement of the pituitary gland, or in most cases a benign tumor, causes an overproduction of the growth hormone which basically tells the body "hey, growth plates, time to take it up a notch." and goes full haywire which often ends up in rapid growth before the growth plates fuse. This is caused by either a deletion or mutation of the AIP gene. This gene regulates cell growth, division, and survival, often acting as a tumor suppressor by controlling cell proliferation, especially in the pituitary gland. Other syndromes can also cause this with one example being Carney complex. This is a genetic condition that affects skin pigmntation and creates benign tumors in your heart, skin and endocrine system. GH-secreting pituitary adenomas (non-cancerous tumor) occur in about 10% to 13% of Carney complex cases and usually have a slow progression. There are multiple other disorders that can cause gigantism (see bottom for list of disorders if you are curious.) But all usually cause non-cancerous tumors to form near the pituitary gland, which is gigantism's most common cause. Now, this continous growth can cause symptoms such as: -large hands and feet -thick toes and fingers -enlarged jaw -significant underbite -enlarged tongue, nose, and lips -deepening voice in boys -joint pain -headaches -difficulty sleeping and/or snoring -heart problems -vision problems Now, there are two types, acromegaly occuring in children before teen years end, and the other where it occurs in adults after the growth plates are fused. Now, crow will be noticeably larger as a kit and will continue to grow until probably after apprenticeship. Crow will go through many complex struggles and will have to fight to overcome them as he gets older. Ranging from joint pain, muscle weakness, to vision impairment and it being hard to even eat maybe due to an extreme under bite caused by this condition. He may feel early on that he may stick out or doesn't belong or that his size is his only defining feature. (Which it isn't and will not be of course.) He will experience joint pain often, and doing things normal kits would do will prove to be difficult. Multiple endocrine neoplasias (MEN) type 1 or type 4 Neurofibromatosis Familial isolated pituitary adenomas (FIPA) McCune-Albright syndrome Carney Complex This is the end of what I learned on gigantism on crow's disorder, if you are curious to find out more on it you can check some of the sources I found the info on! (I heavily encourage you to) v