Use arrow keys to move the Really Derpy Omega Slime, avoid kitties, arrows, red walls and TNT, step on the ice-blue warp panel to get to the boss stage, press s to create a slime, press d to launch a fireball in a random place, press w to summon the Hand of Doom, and if you kill Bruno, Catlord, you should be able to win! Easier said than done, though-by a lot.
See End the Reign of the Derpy Slimes and This cat HATES derpy slimes by Max Cooke. Also thanks to Ritu_LS_Summer for letting me remix the template.