Basically, you have to keep all the buttons green, or pressed. They mean the same thing. You must multitask by keeping the cursor on the one on the left-hand bottom. You can leave it, but you must put your mouse back on it later for at least 1 second, or you lose. You must also continually press the button with the four lines on it. When you press it, it will give you a countdown until you must press it again. In medium and brutal mode, you will have a very weird looking one. It is like the other one, where you must click it every once in a while, except while it is not pressed and is counting its way down before you lose, it will teleport around. Click it before it starts teleporting, otherwise you will get confused, and will result in a lose. Keep all the buttons pressed, and you will get a high score. Scores are determined by how long you can manage the buttons, and by what difficulty you choose. The higher difficulty, the higher the score.
Lots of stuff. Very glitchy and will mess up a lot.