Basically, just talk to her. A lot of the options end the game because you were too stubborn to choose the other ones, just a heads up. Also if you say yes to when she asks you if you're Plankton, HEADPHONE. WARNING.
All rights to go Nickelodeon for the characters, personalities, art, and main ideas and a few go to me for voicing Karen and Plankton and making this. I DID NOT FINISH THE REVENGE OPTION so DO NOT QUESTION IT