Gender dysphoria is the feeling of discomfort or distress that might occur in people whose gender identity differs from their sex assigned at birth or sex-related physical characteristics. Transgender and gender-nonconforming people might experience gender dysphoria at some point in their lives Gender dysphoria can feel different for everyone. It can manifest as distress, depression, anxiety, restlessness or unhappiness. It might feel like anger or sadness, or feeling slighted or negative about your body, or like there are parts of you missing.