Intrinsic apoptosis is a process in which the cell kills itself as a result of DNA damage. It does this to prevent disorder such as cancer. Space to go to next slide
In the cytoplasm, there exists a protein BAX or BAK that remains inhibited by protein Bcl(B cell lymphoma)-2 or Bcl-x. When the cell wants to do apoptosis, it releases a signal that inhibits Bcl-2 from binding to BAX. The now active BAX drills into mitochondria to create pores, releasing various proteins. One of them is cytochrome C(or CYT C). In the cytosol, it binds to APAF-1 (apoptotic protease activating factor 1). As its name states APAF is a protease activating factor. Proteases are proteins that are responsible for degrading proteins. Some examples are caspase (which directly cleave proteins when activated) and proteosomes (which degrades proteins when tagged). When the APAF-1 - cyt C complex assembles to form the hexamer known as the apoptosome
