Press the "a" key to add, the "m" key to multiply, or the "e" key to solve an exponent. Let me know if you run into any problems, or want to know more about how it works... By "very big numbers" I mean like googol+ (1e+100 or more) I wouldn't use more than 3 digits for the power of an exponent though because it will probably take a while... Also, reduce the base if you're using a high power...
The "Say()" block in Scratch doesn't support enough digits for some numbers to be fully displayed, so if your number looks too short, it probably got cutoff. (you can see the whole number by clicking on the "output" variable in the editor) This is more of a proof-of-concept project, so it's not all that efficient. It does work though, and that's what I was going for... Only works with positive integers. Any non-numeric values entered are automatically treated as 0. (e.g., if you add "1a" and "2b", that's just 10 and 20 = 30)